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- Renal insufficiency due to obstructive uropathy from local extension of the tumor or postsurgical or postradiotherapy changes
→ 적절한 dose adjustment 필요함.
(e.g. Use of cisplatin in bladder, germ cell tumor, Use of MTX in ileal conduit and neobladder)
- Local extension in the pelvis
→ local pelvic relapses have the potential to be symptomatic and painful
→ In patient with prior RT, systemic therapy may be important for palliation.