성기단순포진 편집하기 (부분)

====무증상흘림 (asymptomatic shedding)====

*무증상흘림이란 감염된 환자에서 임상징후나 증상이 없이 바이러스가 만들어지는 경우로 전염성이 있어 성매개감염 전파의 위험이 높은 시기이다.<ref name="Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons.">Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-850. </ref>

*성기 HSV-2형에 감염된 여성이 HSV-1형에 감염된 여성보다 높은 무증상흘림 유병률을 가진다 (105일간의 평균 추적관찰 기간 중 55% vs. 29%).<ref name="Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons.">Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-850. </ref>

*HSV-2형의 무증상흘림은 성기감염증상이 없을 때 보다 증상이 있는 경우에서 일반적이다.<ref name="Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons.">Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-850. </ref><ref name="Genital shedding of herpes simplex virus among men.">Wald A, Zeh J, Selke S, et al. Genital shedding of herpes simplex virus among men. J Infect Dis 2002;186(suppl 1):S34-S39. </ref><ref name="Virologic characteristics of subclinical and symptomatic genital herpes infections.">Wald A, Zeh J, Selke S, et al. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med 1995;333:770-775. </ref>

*무증상흘림은 평균감염기간의 2%, 약1.5일 정도에서 일어났다.<ref name="Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons.">Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-850. </ref><ref name="Genital shedding of herpes simplex virus among men.">Wald A, Zeh J, Selke S, et al. Genital shedding of herpes simplex virus among men. J Infect Dis 2002;186(suppl 1):S34-S39. </ref>단순포진 바이러스는 여성에서 외음부, 질, 자궁경부, 직장에서 분리되고, 남성에서는 음경, 회음부, 요도와 소변에서 분리된다.<ref name="Genital shedding of herpes simplex virus among men.">Wald A, Zeh J, Selke S, et al. Genital shedding of herpes simplex virus among men. J Infect Dis 2002;186(suppl 1):S34-S39. </ref><ref name="Virologic characteristics of subclinical and symptomatic genital herpes infections.">Wald A, Zeh J, Selke S, et al. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med 1995;333:770-775. </ref>