생식기클라미디아감염

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  • 메타분석에 따르면 doxycycline 100mg 1일 2회 경구 7일 요법과 azithromycin 1g 경구 단회 요법은 동일한 효과를 보였고, 부작용의 발현에도 차이가 없었다.[1][2][3][4][5][6][7][8][9][10](근거수준 1)
A   생식기 클라미디아 감염의 권장 항생제 요법
   ⋅Azithromycin 1g 경구 단회 요법 
A  또는
   ⋅Doxycycline 100mg 1일 2회 경구 7일 요법
B   환자의 낮은 복약 순응도가 예상되는 경우에는 azithromycin 1g 경구 단회 요법이 권장된다.
  1. Hillis SD, Coles FB, Litchfield B, et al. Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. Sex Transm Dis 1998;25:5-11.
  2. Hammerschlag MR, Golden NH, Oh MK, et al. Single dose of azithromycin for the treatment of genital chlamydial infections in adolescents. J Pediatr 1993;122:961-965.
  3. Johnson RB. The role of azalide antibiotics in the treatment of Chlamydia. Am J Obstet Gynecol 1991;164(6 Pt 2):1794-1796.
  4. Marra F, Marra C, Patrick DM. Cost-effectiveness analysis of azithromycin for Chlamydia trachomatis infection in women: a Canadian perspective. Can J Infect Dis 1997;8:202208.
  5. Martin DH, Mroczkowski TF, Dalu ZA, et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. N Engl J Med 1992;327:921-925.
  6. Nilsen A, Halsos A, Johansen A, et al. A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males. Genitourin Med 1992;68:325-327.
  7. Nuovo J, Melnikow J, Paliescheskey M, King J, Mowers R. Cost-effectiveness analysis of fi ve different antibiotic regimens for the treatment of uncomplicated Chlamydia trachomatis cervicitis. J Am Board Fam Pract 1995;8:7-16.
  8. Ossewaarde JM, Plantema FHF, Rieffe M, Nawrocki RP, De Vries A, van Loon AM. Effi cacy of single-dose azithromycin versus doxycycline in the treatment of cervical infections caused by Chlamydia trachomatis. Eur J Clin Microbiol Infect Dis 1992;11:693-697.
  9. Thorpe EM Jr, Stamm WE, Hook EW 3rd, et al. Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises. Genitourin Med 1996;72:93-97.
  10. Lau CY, Qureshi AK. Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. Sex Transm Dis 2002;29:497-502.